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Brand name: gentamicin
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Gentamicin sulfate USP, betamethasone valerate, USP and clotrimazole, USP ointment reduced discomfort, redness, swelling, exudate, and odor, and exerted a strong antimicrobial effect. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of gentamicin-betamethasone-clotrimazole ointment immediately and flush the ear canal thoroughly with a non-ototoxic solution. The possibility of these phenomena occurring should be considered if gentamicin is administered to animals receiving general anesthesia and/or neuromuscular blocking agents such as succinylcholine or tubocurarine. Usual Pediatric Dose for Tularemia:Use of tularemia as a biological weapon:Contained casualty setting: 15 mg/kg IV twice daily (maximum dose 1 g/day) for 10 days; may switch to oral ciprofloxacin when clinically indicatedThe Working Group on Civilian Biodefense has recommended ciprofloxacin as an alternative to streptomycin and gentamicin if they are contraindicated, not available, or inactive in vitro. 2 g/dayOral: 20 mg/kg every 12 hoursMaximum dose: 2 g/dayUsual Pediatric Dose for Plague:Use of plague as a biological weapon:Treatment, contained-casualty setting: 15 mg/kg IV twice daily for 10 days (maximum 1 g/day); may switch to oral ciprofloxacin when clinically indicatedThe Working Group on Civilian Biodefense has recommended ciprofloxacin as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro. , Gentamicin: Antibacterial Activity, Clinical Pharmacology and Clinical Applications, Medical Times, Vol. Among the gram-positive bacteria, in vitro sensitivity has been shown for Staphylococcus species (including penicillin and methicillin resistant strains) and betahemolytic streptococci which are sensitive to gentamicin. The rate of removal of gentamicin is considerably lower by peritoneal dialysis than it is by hemodialysis. When monitoring gentamicin peak concentrations, dosage should be adjusted so that prolonged levels above 12 mcg/mL are avoided. When monitoring gentamicin trough concentrations, dosage should be adjusted so that levels above 2 mcg/mL are avoided. After initial administration to humans with normal renal function, 30-100% of the gentamicin is recoverable in the urine in 24 hours.

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